Arachidonate epoxygenase: identification of epoxyeicosatrienoic acids in rabbit kidney.
نویسندگان
چکیده
Epoxyeicosatrienoic acids were isolated and purified from female rabbit kidneys. They were identified as a group, prior to resolution, by packed column gas-liquid chromatography-mass spectroscopic techniques as their methyl esters as well as their trimethylsilyl bromohydrin methyl esters. Initial capillary gas-liquid chromatography-mass spectral analysis of the corresponding hydrogenated pentafluorobenzyl esters revealed the presence of the 8,9- and 14,15-epoxyeicosatrienoate regioisomers. These results, in conjunction with the documented in vitro biological activities of the arachidonate epoxygenase metabolites, suggest a role for them in renal function.
منابع مشابه
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عنوان ژورنال:
- Journal of lipid research
دوره 28 7 شماره
صفحات -
تاریخ انتشار 1987